Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD-independent TGF-β signalling pathway

Table 3 Gene expression comparison between hip vs. knee OA, and intact healthy cartilage vs. cartilage with minor degeneration in controls^a

Gene	Hip OA	Knee OA	p	Healthy controls	Controls with minor degeneration	p
Gene	(n = 7)	(n = 25)	p	(n = 14)	(n = 7)	p
TGFB1	6.40 ± 2.16	5.71 ± 2.51	0.42	3.35 ± 1.74	4.36 ± 1.89	0.20
SMAD3	2.55 ± 1.59	2.62 ± 0.76	0.56	1.84 ± 1.46	1.60 ± 1.14	1.00
MMP13	1.74 ± 2.21	0.90 ± 0.74	0.53	0.31 ± 0.53	0.41 ± 0.80	0.82
BMP2	0.15 ± 0.02	0.08 ± 0.01	0.13	1.17 ± 0.31	1.23 ± 0.46	0.65

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