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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1

Fig. 3

Bach1-/- mice have reduced severity of osteoarthritis (OA) in an aging model and a surgical OA model. a Body weight of wild-type mice and Bach1-/- mice at 4 (4 W) and 10 weeks (10 W) and 22 months (22 M) (n = 5–9 animals per time point). b Histological assessment using modified Mankin scoring system of spontaneous cartilage degeneration exacerbated with aging in wild-type mice and Bach1-/- mice. Photographs of a knee from a representative mouse at 22 months old, from each group are also shown. Original magnification × 10; scale bars 200 μm. c Analyses of OA pathology using the semiquantitative scoring system in mice at 22 months old, including synovitis, osteophyte formation, subchondral bone thickening and meniscus degradation. Original magnification × 20; scale bars 100 μm. d Analyses of cartilage pathology in a surgically induced OA model. Original magnification × 20; scale bars 100 μm. e Analyses of OA pathology in a surgically induced OA model, including synovitis, osteophyte formation, subchondral bone thickening and meniscus degradation. Original magnification × 20; scale bars 100 μm. Values are the mean ± SD. Statistical analysis was performed with the Mann–Whitney U test; *P <0.05, **P <0.01 versus wild-type mice

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