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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1

Fig. 4

Expression of microtubule-associated protein 1 light chain 3 (LC3) and superoxide dismutase 2 (SOD2) in articular cartilage. Knee joints from wild-type (WT) mice and Bach1-/- mice were analyzed by immunohistochemistry for LC3 and SOD2. Total number of LC3- and SOD2-positive cells in six fields were counted and the percentage of positive cells was calculated. a Representative immunostaining of articular cartilage from 12-month- (12 M) and 22 month (22 M)-old mice (aging model) (n = 4 per group). b Representative immunostaining of articular cartilage from a surgically induced osteoarthritis (OA) model (n = 4 per group). Original magnification × 20; scale bars 100 μm. Values are the mean ± SD. Statistical analysis was performed with the Mann–Whitney U test; *P <0.05, **P <0.01 versus wild-type mice

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