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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects

Fig. 3

Covariate effects on AMG 403 clearance (CL) and (V c ). Possible covariate effects were explored for individual CL and Vc parameters derived from simultaneous population pharmacokinetics modeling of data from healthy volunteers (HV) and patients with knee osteoarthritis (OA). Effect of body weight on CL (a) and Vc (b) is illustrated with a loess regression line. c The effect of anti-drug antibody (ADA) status (negative (n = 34) or positive (n = 14)) or disease status (HV (n = 30) or patients with knee OA (n = 18)) on CL is presented in box plots (median, 25th, and 75th percentiles; whiskers are 1.5 times the inner-quartile range and dots are outliers)

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