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Table 1 Pretreatment patient characteristics

From: Serum 14-3-3η level is associated with severity and clinical outcomes of rheumatoid arthritis, and its pretreatment level is predictive of DAS28 remission with tocilizumab

Variable Entire cohort 14-3-3η-negative 14-3-3η-positive p Value
Number of patients 149 39 110  
Categorical variables     
 Sex (% female) 128 (86 %) 34 (87 %) 94 (85 %) 0.7937
 RF status (% positive) 126 (85 %) 21 (54 %) 105(95 %) <0.0001
 ACPA status (% positive) 97 (65 %) 20 (67 %)a 78 (98 %)b <0.0001
 14-3-3η status (% positive) 110 (74 %) 0 (0 %) 110 (100 %) <0.0001
 Concomitant use of MTX (%) 117 (79 %) 34 (87 %) 83 (76 %) 0.1733
Continuous variables     
 Age (yr)c 57.3 (14.7) 54.6 (16.1) 58.2 (14.1) 0.1924
 RA duration (mo) 51 (9–150) 34 (9–132) 55 (11–159) 0.3791
 MTX dose (mg/wk) 8.0 (5.0–10.0) 8.0 (6.0–10.0) 8.0 (1.5–10.0) 0.456
 DAS28-ESR 5.35(4.40–6.45) 4.77 (4.10–5.86) 5.62 (4.64–6.57) 0.0101
 HAQd 1.07 (0.60–1.88) 1.00 (0.47–1.88) 1.13 (0.63–1.85) 0.7328
 CDAI 22.2 (14.0–33.5) 16.0 (11.5–27.0) 24.7 (16.2–36.3) 0.015
 SDAI 24.3 (14.3–37.4) 18.8 (11.7–32.7) 26.8 (16.7–38.6) 0.0238
 TJC28 7.0 (4.0–13.5) 5.0 (2.0–12.0) 7.0 (4.0–14.0) 0.0327
 SJC28 6.0 (2.0–9.0) 4.0 (2.0–9.0) 6.5 (2.8–10.0) 0.0466
 SHS 26.5 (4.5–90.8) 14.0 (3.0–88.5) 31.3 (6.9–99.9) 0.1185
 JSN scoree 18.0 (3.0–45.5) 9.0 (1.5–42.5) 19.8 (4.1–47.4)f 0.11
 Erosion scoree 10.5 (2.0–45.5) 5.0 (2.0–40.5) 12.8 (2.5–53.0)f 0.108
 ESR 44.0 (21.5–72.5) 35.0 (17.0–58.0) 47.5 (22.8–80.0) 0.0482
 CRP (mg/dl) 0.83(0.23–3.13) 0.69 (0.20–2.70) 0.99 (0.26–3.44) 0.3769
 RF 60.4 (27.4–171.8) 15.5 (5.8–43.2) 84.5 (41.9–242.1) <0.0001
 ACPA 100.0 (27.4–100) 16.9 (1.9–100)a 100.0 (52.0–100)b 0.0002
 14-3-3η (ng/ml) 0.70 (0.17–5.96) 0.10 (0.04–0.13) 1.70 (0.49–11.0) <0.0001
  1. Abbreviations: ACPA anticyclic citrullinated antibodies, CDAI Clinical Disease Activity Index, CRP C-reactive protein, DAS28-ESR Disease Activity Score in 28 joints with erythrocyte sedimentation rate, ESR erythrocyte sedimentation rate, HAQ Health Assessment Questionnaire, JSN joint space narrowing, MTX methotrexate, RF rheumatoid factor, RA rheumatoid arthritis, SDAI Simple Disease Activity Index, SHS Sharp/van der Heijde score, SJC28 28-joint swollen joint count, TJC28 28-joint tender joint count
  2. All p values were generated based on Mann–Whitney analysis, with the exception of age, which was generated using paired t tests.
  3. aData were available for 30 patients
  4. bACPA values were available for 80 patients
  5. cAge is presented as the mean (standard deviation). All other variables are presented as the median (interquartile range).
  6. dHAQ scores were available for 146 patients
  7. eJSN and erosion scores were available for 147 patients
  8. fJSN and erosion scores were available for 108 patients