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Table 3 Analysis of associations between the minor alleles of the eleven variants and gout

From: Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout

 

European

Polynesian

Meta-analysis

Gene, SNP, minor allele

MAF case

MAF control

OR (95 % CI)

P

MAF case

MAF control

OR (95 % CI)

P

OR (StdErr)

P

NLRP3, rs10754558, G

0.408

0.418

0.95 (0.87–1.04)

0.25

0.459

0.434

1.07 (0.91–1.24)

0.42

0.96 (0.036)

0.44

NLRP3, rs35829419, A

0.046

0.047

0.88 (0.71–1.07)

0.20

0.004

0.012

0.58 (0.20–1.53)

0.29

0.87 (0.098)

0.15

NLRP3, rs7512998, C

0.170

0.160

1.09 (0.94–1.27)

0.25

0.033

0.045

1.03 (0.67–1.60)

0.88

1.08 (0.075)

0.29

CARD8, rs2043211, T

0.338

0.321

1.11 (1.01–1.22)

0.023

0.499

0.439

1.15 (0.98–1.35)

0.078

1.12 (0.042)

0.007

IL1B, rs1143623, G

0.278

0.266

1.09 (0.99–1.20)

0.066

0.532

0.481

1.14 (0.98–1.33)

0.098

1.10 (0.042)

0.020

TLR2, rs4696480, T

0.495

0.499

1.02 (0.93–1.11)

0.68

0.482

0.490

0.98 (0.84–1.15)

0.84

1.01 (0.036)

0.74

CD14, rs2569190, A

0.496

0.475

1.08 (0.99–1.18)

0.070

0.576

0.542

1.07 (0.92–1.26)

0.37

1.08 (0.036)

0.036

MYD88, rs6853, G

0.112

0.120

0.88 (0.77–1.00)

0.059

0.026

0.028

1.18 (0.71–1.98)

0.52

0.90 (0.068)

0.11

P2RX7, rs17525809, C

0.071

0.068

1.09 (0.92–1.29)

0.30

0.056

0.068

0.78 (0.56–1.08)

0.13

1.01 (0.080)

0.87

DAPK1, rs4878104, T

0.358

0.353

1.02 (0.93–1.11)

0.72

0.701

0.622

1.13 (0.96–1.34)

0.14

1.05 (0.044)

0.32

TNXIP, rs7212, G

0.050

0.041

1.27 (1.04–1.55)

0.020

0.191

0.175

1.00 (0.82–1.22)

0.98

1.13 (0.071)

0.091

  1. SNP single nucleotide polymorphism, MAF minor allele frequency, OR odds ratio, StdErr standard error