Table 4 Interaction analysis: genotype combinations of CARD8 rs2043211 and NLRP3 rs10754558, CARD8 rs2043211 and IL1B rs1143623, and NLRP3 rs10754558 and IL1B rs1143623

rs10754558- rs2043211 (NLRP3-CARD8)

CC/AA

318 (0.127)

1,862 (0.155)

1.00

CC/AT

376 (0.150)

1,722 (0.144)

1.17 (0.96–1.42)

0.11

CC/TT

133 (0.053)

476 (0.040)

1.55 (1.18–2.04)

0.001

CG/AA

450 (0.180)

2,606 (0.217)

0.94 (0.78–1.13)

0.53

CG/AT

583 (0.233)

2,565 (0.214)

1.16 (0.97–1.38)

0.11

CG/TT

186 (0.074)

635 (0.053)

1.45 (1.11–1.81)

0.006

GG/AA

172 (0.069)

964 (0.080)

0.95 (0.75–1.20)

0.65

GG/AT

206 (0.082)

905 (0.076)

1.22 (0.97–1.54)

0.085

GG/TT

80 (0.032)

258 (0.022)

1.71 (1.23–2.39)

0.002

rs1143623-rs2043211 (IL1B-CARD8)

CC/AA

430 (0.174)

2,821 (0.236)

1.00

CC/AT

488 (0.197)

2,740 (0.229)

1.13 (0.96–1.32)

0.16

CC/TT

136 (0.055)

644 (0.054)

1.26 (0.99–1.62)

0.066

CG/AA

390 (0.157)

2,182 (0.182)

1.10 (0.92–1.31)

0.28

CG/AT

495 (0.200)

1,979 (0.165)

1.48 (1.25–1.75)

4.3 × 10⁻⁶

CG/TT

162 (0.065)

575 (0.048)

1.74 (1.36–2.22)

8.7 × 10⁻⁶

GG/AA

112 (0.045)

425 (0.036)

1.33 (1.00–1.77)

0.049

GG/AT

166 (0.067)

465 (0.039)

1.61 (1.25–2.07)

2.0 × 10⁻⁴

GG/TT

100 (0.040)

147 (0.012)

3.77 (2.65–5.34)

<1.0 × 10⁻⁶

rs10754558- rs1143623 (NLRP3-IL1B)

CC/CC

352 (0.141)

2,147 (0.179)

1.00

CC/CG

346 (0.139)

1,574 (0.131)

1.32 (1.09–1.60)

0.005

CC/GG

128 (0.051)

340 (0.028)

2.09 (1.57–2.78)

<1.0 × 10⁻⁶

CG/CC

497 (0.200)

2,963 (0.247)

1.00 (0.84–1.19)

1.00

CG/CG

529 (0.212)

2,312 (0.193)

1.30 (1.09–1.54)

0.004

CG/GG

184 (0.074)

524 (0.044)

1.43 (1.11–1.85)

0.005

GG/CC

209 (0.084)

1,099 (0.092)

1.22 (0.98–1.52)

0.072

GG/CG

179 (0.072)

851 (0.071)

1.14 (0.90–1.44)

0.272

GG/GG

66 (0.026)

173 (0.014)

1.70 (1.17–2.48)

0.006