|
Disease activity indicators
|
Accuracy
|
P
|
95 % CI
|
Cutoff point
|
PPV (%)
|
NPV (%)
|
OR (95 % CI)
|
P
|
|---|
|
Baseline
| | | | | | | | |
|
Serum MMP-3
|
0.721
|
0.010
|
0.572 ~ 0.870
|
159 ng/ml
|
46.7
|
92.3
|
10.500 (2.097 ~ 52.581)
|
0.004
|
|
Total Sharp score
|
0.753
|
0.003
|
0.613 ~ 0.893
|
15
|
54.5
|
88.2
|
9.000 (2.359 ~ 34.334)
|
0.001
|
|
1st month
| | | | | | | | |
|
CRP
|
0.680
|
0.037
|
0.525 ~ 0.835
|
1.76 mg/dl
|
66.7
|
78.7
|
7.400 (1.567 ~ 34.935)
|
0.011
|
|
Serum MMP-3
|
0.758
|
0.003
|
0.605 ~ 0.911
|
264 ng/ml
|
64.7
|
87.2
|
12.467 (3.175 ~ 48.950)
|
< 0.001
|
|
3rd month
| | | | | | | | |
|
Serum MMP-3
|
0.766
|
0.002
|
0.606 ~ 0.926
|
178 ng/ml
|
64.7
|
87.2
|
15.857 (3.412 ~ 73.687)
|
< 0.001
|
|
6th month
| | | | | | | | |
|
28SJC
|
0.667
|
0.052
|
0.503 ~ 0.832
|
NA
|
NA
|
NA
|
NA
|
NA
|
|
CRP
|
0.681
|
0.035
|
0.525 ~ 0.838
|
0.64 mg/dl
|
58.3
|
79.5
|
5.444 (1.395 ~ 21.244)
|
0.015
|
|
Serum MMP-3
|
0.830
|
< 0.001
|
0.696 ~ 0.963
|
161 ng/ml
|
75.0
|
90.0
|
27.000 (5.834 ~ 24.962)
|
< 0.001
|
-
aAccuracy of predictive value was determined by ROC curve analysis; OR of predictors was determined by univariate logistic regression analysis according to the cutoff point
-
28SJC 28-joint swollen joint count, PrGA provider global assessment of disease activity, CRP C-reactive protein, ESR erythrocyte sedimentation rate, MMP-3 matrix metalloproteinase-3, RF rheumatoid factor, anti-CCP anti-cyclic citrullinated peptide antibody, DAS28 Disease Activity Score 28-joint assessment, SDAI simplified disease activity index, PPV positive predictive value, NPV negative predictive value, ROC receiver operating characteristic; OR odds ratio, CI confidence interval, NA not applicable
