Fig. 3

Measurement of intraepidermal nerve fibres (IENFs) in the paw pad and back skin. Numbers of IENFs per millimetre in control rats, acute antigen-induced arthritis (AIA) rats, and chronic AIA rats, which are immunopositive for protein gene product 9.5 (PGP 9.5) (a, b) and calcitonin gene–related peptide (CGRP) (c) in the paw pad (a, c) and back skin (b). Counts of IENFs immunopositive to PGP 9.5 and CGRP did not show significant changes