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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Antigen-induced arthritis in rats is associated with increased growth-associated protein 43–positive intraepidermal nerve fibres remote from the joint

Fig. 6

Plots for growth-associated protein 43 (GAP-43)–positive intraepidermal nerve fibres (IENFs) in paw skin and behavioural data of antigen-induced arthritis (AIA) rats. a Relationship between the relative weight-bearing on the inflamed hind limb and IENFs marked by antibodies against GAP-43 in the ipsilateral paw pad skin. Relative weight-bearing for control animals was defined as 50 %, with equal weight on both legs. Control values are parenthesized. b Plot of the mechanical threshold at the inflamed knee and GAP-43–positive IENFs in the ipsilateral paw pad skin. Control values in parentheses were set at 234.5 g, which was the average baseline value for animals before induction of AIA (standard deviation was ±20.6 g). c Relationship between the mechanical threshold of the ipsilateral paw pad and GAP-43–positive IENFs in the ipsilateral paw pad skin. Control values in parentheses were determined as the mean of baseline values from acute and chronic AIA animals before induction of AIA (27.9 g ± 7.6 g)

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