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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Investigation of the cytokine response to NF-κB decoy oligonucleotide coated polysaccharide based nanoparticles in rheumatoid arthritis in vitro models

Fig. 5

ELISA was performed to determine levels of IL-8 secretion by primary RA synovial fibroblast cells, after treatment with ODN alone, NP-ODN, NP-MTX, NP-ODN-MTX, and MTX alone, and stimulation with IL-1β at (a) 24 hours and (b) 48 hours. Results are expressed as fold changes of IL-8 levels relative to an untreated control (solid line at 1). One-way ANOVA followed by Holm–Sidak multiple comparisons testing was used to determine the impact of treatment on IL-8 secretion. *Significant difference from the control. †Significant difference from ODN alone. Data presented as mean ± SD (n = 4). IL interleukin, MTX methotrexate, NP PSA-TMC nanoparticles, ODN oligonucleotide

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Arthritis Research & Therapy

ISSN: 1478-6362

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