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Table 1 Biodistribution of 68Ga-DOTA-Siglec-9 in rabbits with mild synovitis

From: 68Ga-DOTA-Siglec-9 – a new imaging tool to detect synovitis

Tissue

Standardized uptake value

Adrenal gland

0.4 ± 0.1

Blood

1.8 ± 0.6

Control synovium

0.8 ± 0.2

Heart

0.5 ± 0.1

Inflamed synovium

1.3 ± 0.2

Intraperitoneal fat

0.2 ± 0.1

Kidney

4.3 ± 1.0

Liver

1.4 ± 0.7

Lung

0.8 ± 0.2

Lymph nodes

0.8 ± 0.2

Muscle

0.2 ± 0.1

Skin

0.9 ± 0.2

Spleen

3.1 ± 1.9

Urine

42 ± 35

  1. Results are expressed as mean ± SD and represent ex vivo gamma counting of excised tissue samples obtained 30 minutes after tracer injection