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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: p21 deficiency is susceptible to osteoarthritis through STAT3 phosphorylation

Fig. 4

p21 levels influence the number of p-STAT3-positive cells in DMM mice. Cartilage tissue samples were collected from the right knee (sham or DMM surgery) of (a) p21+/+ (sham), (b) p21−/− (sham), (c) p21+/+ (DMM), and (d) p21−/− (DMM) mice. e Percentages of pSTAT3-positive stained cells (number of positive cells/number of total cells) with 95 % CI. The sections are stained for p-STAT3 antibody and counterstained with methyl green. Six mice were analyzed for each of the following groups: p21+/+ sham, p21+/+ DMM, p21−/− sham, and p21−/− DMM. CI confidence interval, DMM destabilization of the medial meniscus, p-STAT3 phosphorylated signal transducer and activator of transcription 3

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