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Table 1 Shows the serum biomarkers of bone and cartilage metabolism at the end of 5 and 10 weeks of the study

From: Effect of antiresorptive and anabolic bone therapy on development of osteoarthritis in a posttraumatic rat model of OA

   

5 weeks

  

Parameter

Unit

Sham

MM + veh

MM + Zol

MM + PTH

Osteocalcin

ng/mL

32.8 ± 5.0

32.1 ± 5.1

24.3 ± 2.1**

60.4 ± 16.9**

P1NP

ng/mL

277.2 ± 73.7

274.8 ± 44.2

243.8 ± 43.8

285.5 ± 44.1

CTX-I

ng/mL

22.5 ± 4.4

25.0 ± 5.0

28.9 ± 4.7

30.6 ± 6.3

CTX-II

ng/mL

30.5 ± 9.9

39.3 ± 8.7a

13.2 ± 8.5**

30.4 ± 4.0*

   

10 weeks

  

Osteocalcin

ng/mL

47.1 ± 11.5

38.1 ± 9.3

27.8 ± 11.5

30.7 ± 3.9

P1NP

ng/mL

146.0 ± 22.0

174.7 ± 26.1

134.8 ± 29.7

163.7 ± 26.8

CTX-I

ng/mL

36.7 ± 3.1

40.5 ± 7.9

49.3 ± 7.6

36.2 ± 4.1

CTX-II

ng/mL

14.4 ± 4.1

20.9 ± 5.6a

11.6 ± 3.2*

21.4 ± 5.3

  1. Sham, sham control group, MM + veh medial meniscectomy (MM) vehicle-treated group, MM + Zol MM + zoledronate group, MM + PTH MM + parathyroid hormone group, P1NP procollagen type 1 N-terminal propeptide, CTX-I cross-linked type I collagen C-terminal telopeptide, CTX-II C-terminal telopeptide of type II collagen
  2. * p < 0.05 or ** < 0.01 relative to MM + veh rats
  3. a p < 0.05 relative to sham rats