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Table 1 Shows the serum biomarkers of bone and cartilage metabolism at the end of 5 and 10 weeks of the study

From: Effect of antiresorptive and anabolic bone therapy on development of osteoarthritis in a posttraumatic rat model of OA

    5 weeks   
Parameter Unit Sham MM + veh MM + Zol MM + PTH
Osteocalcin ng/mL 32.8 ± 5.0 32.1 ± 5.1 24.3 ± 2.1** 60.4 ± 16.9**
P1NP ng/mL 277.2 ± 73.7 274.8 ± 44.2 243.8 ± 43.8 285.5 ± 44.1
CTX-I ng/mL 22.5 ± 4.4 25.0 ± 5.0 28.9 ± 4.7 30.6 ± 6.3
CTX-II ng/mL 30.5 ± 9.9 39.3 ± 8.7a 13.2 ± 8.5** 30.4 ± 4.0*
    10 weeks   
Osteocalcin ng/mL 47.1 ± 11.5 38.1 ± 9.3 27.8 ± 11.5 30.7 ± 3.9
P1NP ng/mL 146.0 ± 22.0 174.7 ± 26.1 134.8 ± 29.7 163.7 ± 26.8
CTX-I ng/mL 36.7 ± 3.1 40.5 ± 7.9 49.3 ± 7.6 36.2 ± 4.1
CTX-II ng/mL 14.4 ± 4.1 20.9 ± 5.6a 11.6 ± 3.2* 21.4 ± 5.3
  1. Sham, sham control group, MM + veh medial meniscectomy (MM) vehicle-treated group, MM + Zol MM + zoledronate group, MM + PTH MM + parathyroid hormone group, P1NP procollagen type 1 N-terminal propeptide, CTX-I cross-linked type I collagen C-terminal telopeptide, CTX-II C-terminal telopeptide of type II collagen
  2. * p < 0.05 or ** < 0.01 relative to MM + veh rats
  3. a p < 0.05 relative to sham rats