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Table 1 Demographic and clinical characteristics of the patients with rheumatoid arthritis

From: PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts

  Cohort
Variable HCSC-RAC PEARL PAZ EAC Wichita NDB
Total patients, n 402 81 42 597 100 567
Total sets of X-rays, n 637 210 173 3143 353 567
Female sex, n (%) 304 (75.62) 62 (76.54) 26 (61.90) 402 (67.3) 70 (70.0) 444 (78.3)
Age at diagnosis, yr, mean (SD) 57.09 (13.61) 55.39 (17.33) 53.11 (14.77) 57.1 (15.6) 49.1 (11.6) 48.7 (12.7)
Year at RA diagnosis, range 1976–2011 2000–2011 1992–2004 1993–2006 1963–1999 1980–1999
RF positivity, n (%) 260 (64.68) 47 (58.02) 35 (83.33) 342 (57.6)a
ACPA positivity, n (%) 167 (47.18)b 38 (47.50)c 33 (78.57) 309 (52.8)d 96 (97.0)e 452 (79.7)
Radiographic follow-up, yr 15 5 10 7 15 NA
  1. ACPA anticitrullinated peptide antibodies, EAC Leiden Early Arthritis Clinic cohort, HCSC-RAC Hospital Clínico San Carlos rheumatoid arthritis cohort, NDB National Databank for Rheumatic Diseases cohort, PAZ Hospital Universitario de La Paz early arthritis cohort, PEARL Princesa Early Arthritis Register Longitudinal study cohort, RA rheumatoid arthritis, RF rheumatoid factor, SD standard deviation
  2. aRF status missing in three patients from the EAC cohort
  3. bACPA status missing in 60 patients from the HCSC-RAC cohort
  4. cACPA status missing in one patient from the PEARL cohort
  5. dACPA status missing in 12 patients from the EAC cohort
  6. eACPA status missing in one patients from the Wichita cohort