Skip to main content

Table 3 Candidate single-nucleotide polymorphisms selected for replication from the time-varying effect analysis

From: PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts

    

Discovery cohort

Replication cohort

Overall cohort (n = 6)

SNP

Position

RegulomeDB score

Westra et al. [27] cis p value (gene)

Pooled ES (95 % CI)

Pooled p valuea

I 2 value

Pooled ES (95 % CI)

Pooled p valuea

I 2 value

Pooled ES (95 % CI)

Pooled p valuea

I 2 value

rs80058440

40350930

6

–

1.05 (1.01–1.08)

0.01

0

0.99 (0.97–1.02)

0.62

–

1.01 (0.99–1.03)

0.18

0.50

rs6451489

40357663

5

–

0.97 (0.95–0.99)

0.01

0.15

1.01 (0.99–1.02)

0.40

0

0.99 (0.98–1.01)

0.46

0.43

rs12515934

40376930

2b

–

1.05 (1.01–1.08)

0.004

0.27

1.01 (0.98–1.03)

0.54

0

1.02 (1.002–1.04)

0.03

0.24

rs12520940

40382428

4

–

1.04 (1.01–1.07)

0.01

0

0.99 (0.97–1.01)

0.25

0

1.003 (0.99–1.02)

0.53

0.47

rs13160782

40428061

4

–

1.04 (1.01–1.06)

0.01

0

1.01 (1.00–1.03)

0.16

0.28

1.02 (1.005–1.03)

0.01

0.05

rs76523431

40443657

6

–

1.10 (1.01–1.19)

0.02

0.36

1.10 (1.04–1.15)

3.32 × 10−4

0.24

1.10 (1.05–1.14)

2.10 × 10−5

0.13

rs78607701

40447491

4

–

0.93 (0.89–0.98)

0.004

0

0.99 (0.95–1.03)

0.51

0

0.97 (0.94–0.99)

0.02

0

rs58752461

40481432

4

–

0.97 (0.94–0.99)

0.03

0

0.98 (0.96–1.00)

0.08

0

0.98 (0.96–0.99)

0.01

0

rs4587119

40492734

–

1.16 × 10−16 (PTGER4)

1.04 (1.004–1.07)

0.03

0.31

1.00 (0.98–1.03)

0.87

0

1.01 (0.99–1.03)

0.14

0.27

rs13181935

40493646

–

6.88 × 10−11 (PTGER4)

1.05 (1.01–1.08)

0.01

0

1.01 (0.98–1.03)

0.61

0

1.02 (1.0002–1.04)

0.05

0.17

rs7707931

40496930

6

3.68 × 10–13 (PTGER4)

1.03 (1.004–1.06)

0.02

0

1.01 (0.99–1.02)

0.58

0

1.01 (0.99–1.03)

0.08

0

rs74630635

40510535

–

–

1.05 (1.01–1.10)

0.02

0

1.05 (1.01–1.09)

0.01

0.22

1.05 (1.02–1.08)

6.40 × 10−4

0

rs7705019

40587804

3a

–

1.04 (1.01–1.08)

0.03

0.49

1.01 (0.99–1.03)

0.40

0

1.02 (1.003–1.04)

0.03

0.36

rs2174550

40602383

–

–

0.93 (0.88–0.99)

0.04

0.33

1.00 (0.98–1.03)

0.83

0.44

0.99 (0.97–1.02)

0.15

0.53

rs4409138

40603605

2b

–

1.04 (1.01–1.07)

0.01

0.37

1.01 (0.99–1.03)

0.37

0

1.02 (1.002–1.04)

0.03

0.24

rs924967

40615122

–

2.36 × 10−11 (PTGER4)

1.04 (1.01–1.07)

0.01

0.26

1.01 (0.99–1.03)

0.38

0

1.02 (1.002–1.04)

0.03

0.18

rs76504641

40624582

6

–

0.96 (0.92–0.99)

0.02

0

1.00 (0.98–1.02)

0.98

0

0.99 (0.97–1.01)

0.28

0.35

rs4432939

40671099

–

–

0.97 (0.95–0.99)

0.03

0

0.98 (0.96–1.00)

0.05

0

0.98 (0.96–0.99)

0.004

0

rs45480797

40680964

2a

–

0.95 (0.91–0.99)

0.01

0

0.98 (0.95–1.01)

0.24

0

0.97 (0.95–0.99)

0.02

0

rs78733746

40727730

4

–

0.93 (0.88–0.99)

0.02

0

1.00 (0.96–1.04)

0.93

0

0.98 (0.95–1.01)

0.19

0

  1. CI confidence interval, ES effect size, PTGER4 prostaglandin E receptor 4, SNP single-nucleotide polymorphism
  2. Data are based on pooled analysis in the discovery cohort, replication cohort, and all six overall cohorts
  3. aRandom effects p value was used if I 2 value was ≥0.4. Otherwise, fixed effects p-value was used
Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us