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Table 3 Candidate single-nucleotide polymorphisms selected for replication from the time-varying effect analysis

From: PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts

     Discovery cohort Replication cohort Overall cohort (n = 6)
SNP Position RegulomeDB score Westra et al. [27] cis p value (gene) Pooled ES (95 % CI) Pooled p valuea I 2 value Pooled ES (95 % CI) Pooled p valuea I 2 value Pooled ES (95 % CI) Pooled p valuea I 2 value
rs80058440 40350930 6 1.05 (1.01–1.08) 0.01 0 0.99 (0.97–1.02) 0.62 1.01 (0.99–1.03) 0.18 0.50
rs6451489 40357663 5 0.97 (0.95–0.99) 0.01 0.15 1.01 (0.99–1.02) 0.40 0 0.99 (0.98–1.01) 0.46 0.43
rs12515934 40376930 2b 1.05 (1.01–1.08) 0.004 0.27 1.01 (0.98–1.03) 0.54 0 1.02 (1.002–1.04) 0.03 0.24
rs12520940 40382428 4 1.04 (1.01–1.07) 0.01 0 0.99 (0.97–1.01) 0.25 0 1.003 (0.99–1.02) 0.53 0.47
rs13160782 40428061 4 1.04 (1.01–1.06) 0.01 0 1.01 (1.00–1.03) 0.16 0.28 1.02 (1.005–1.03) 0.01 0.05
rs76523431 40443657 6 1.10 (1.01–1.19) 0.02 0.36 1.10 (1.04–1.15) 3.32 × 10−4 0.24 1.10 (1.05–1.14) 2.10 × 10−5 0.13
rs78607701 40447491 4 0.93 (0.89–0.98) 0.004 0 0.99 (0.95–1.03) 0.51 0 0.97 (0.94–0.99) 0.02 0
rs58752461 40481432 4 0.97 (0.94–0.99) 0.03 0 0.98 (0.96–1.00) 0.08 0 0.98 (0.96–0.99) 0.01 0
rs4587119 40492734 1.16 × 10−16 (PTGER4) 1.04 (1.004–1.07) 0.03 0.31 1.00 (0.98–1.03) 0.87 0 1.01 (0.99–1.03) 0.14 0.27
rs13181935 40493646 6.88 × 10−11 (PTGER4) 1.05 (1.01–1.08) 0.01 0 1.01 (0.98–1.03) 0.61 0 1.02 (1.0002–1.04) 0.05 0.17
rs7707931 40496930 6 3.68 × 10–13 (PTGER4) 1.03 (1.004–1.06) 0.02 0 1.01 (0.99–1.02) 0.58 0 1.01 (0.99–1.03) 0.08 0
rs74630635 40510535 1.05 (1.01–1.10) 0.02 0 1.05 (1.01–1.09) 0.01 0.22 1.05 (1.02–1.08) 6.40 × 10−4 0
rs7705019 40587804 3a 1.04 (1.01–1.08) 0.03 0.49 1.01 (0.99–1.03) 0.40 0 1.02 (1.003–1.04) 0.03 0.36
rs2174550 40602383 0.93 (0.88–0.99) 0.04 0.33 1.00 (0.98–1.03) 0.83 0.44 0.99 (0.97–1.02) 0.15 0.53
rs4409138 40603605 2b 1.04 (1.01–1.07) 0.01 0.37 1.01 (0.99–1.03) 0.37 0 1.02 (1.002–1.04) 0.03 0.24
rs924967 40615122 2.36 × 10−11 (PTGER4) 1.04 (1.01–1.07) 0.01 0.26 1.01 (0.99–1.03) 0.38 0 1.02 (1.002–1.04) 0.03 0.18
rs76504641 40624582 6 0.96 (0.92–0.99) 0.02 0 1.00 (0.98–1.02) 0.98 0 0.99 (0.97–1.01) 0.28 0.35
rs4432939 40671099 0.97 (0.95–0.99) 0.03 0 0.98 (0.96–1.00) 0.05 0 0.98 (0.96–0.99) 0.004 0
rs45480797 40680964 2a 0.95 (0.91–0.99) 0.01 0 0.98 (0.95–1.01) 0.24 0 0.97 (0.95–0.99) 0.02 0
rs78733746 40727730 4 0.93 (0.88–0.99) 0.02 0 1.00 (0.96–1.04) 0.93 0 0.98 (0.95–1.01) 0.19 0
  1. CI confidence interval, ES effect size, PTGER4 prostaglandin E receptor 4, SNP single-nucleotide polymorphism
  2. Data are based on pooled analysis in the discovery cohort, replication cohort, and all six overall cohorts
  3. aRandom effects p value was used if I 2 value was ≥0.4. Otherwise, fixed effects p-value was used