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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: A novel method to detect articular chondrocyte death during early stages of osteoarthritis using a non-invasive ApoPep-1 probe

Fig. 5

Assessment of osteoarthritis (OA) progression using the ApoPep-1 probe. a In vivo optical images 30 minutes after intravenous injection of ApoPep-1 or control probe at different stages of OA development (1, 2, 4, and 8 weeks after destabilization of the medial meniscus (DMM) or sham operation). Photo of one representative mouse for each group. Quantified mean ± SD are shown for each group (arbitrary units): Sham-ApoPep-1 sham operation and Apo-Pep-1 injection (n = 6), OA-Control OA operation and control peptide injection (n = 8), OA-ApoPep-1 OA operation and ApoPep-1 injection (n = 8), wks weeks. b Ex vivo optical images of mouse joints 2 hours after intravenous injection of ApoPep-1 at different stages of OA development (2, 4, and 8 weeks after sham operation or DMM) (n = 3/group). Quantified mean ± SD are shown for each group (arbitrary units); *p <0.05 OA-ApoPep-1 compared to Sham-ApoPep-1, # p <0.05 OA-ApoPep-1 compared to OA-Control. NC normalized count

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