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Table 1 Patient demographics, low back pain characteristics, and MRI features at baseline

From: Tumor necrosis factor-α blockade in recurrent and disabling chronic sciatica associated with post-operative peridural lumbar fibrosis: results of a double-blind, placebo randomized controlled study

  IFX group Placebo group All patients
n = 18 n = 17 n = 35
Age (years), median (IQR) 45.0 (38.0–52.0) 43.0 (40.0–48.0) 44.0 (38.0–8.3)
Male sex, n (%) 11 (61.1) 7 (41.2) 18 (51.4)
BMI (kg/m2), median (IQR) 27.9 (24.8–29.8) 25.8 (23.0–29.0) 26.9 (24.4–29.8)
Retired, n (%) 0 (0) 0 (0) 0 (0)
Sick leave, n (%) 16 (88.9) 15 (88.2) 31 (88.6)
Lumbar pain (VAS (0–100 mm)), median (IQR) 60.0 (41.0–80.0) 50.0 (26.0–60.0) 58.0 (35.0–70.0)
Radicular pain, (VAS (0–100 mm)), median (IQR) 70.0 (65.0–85.0) 55.0 (50.0–70.0) 65.0 (45.0–76.0)
Neuropathic pain, n (%) 18 (100) 11 (64.7) 29 (82.9)
Neuropathic pain (VAS (0–100 mm)), median (IQR) 62.5 (40.0–75.0) 45.0 (41.0–75.0) 50.0 (41.0–70.0)
Québec score (0–100), median (IQR) 55.0 (37.0–68.0) 45.0 (31.0–62.0) 48.0 (37.0–63.0)
HAD-S, median (IQR)
 HAD anxiety score (0–21) 10.0 (6.0–15.0) 10.0 (8.0–14.0) 10.0 (6.0–14.0)
 HAD depression score (0–21) 9.0 (6.0–11.0) 7.0 (5.0–9.0) 7.5 (6.0–11.0)
FAB-Q, median (IQR)    
 FAB-Q work subscale score (0–42) 33.0 (21.0–41.0) 24.0 (19.0–35.0) 30.0 (20.0–39.0)
 FAB-Q physical activity subscale score (0–24) 14.0 (11.0–19.0) 16.0 (10.0–19.0) 14.0 (10.0–20.0)
Number of lumbar surgeries, n (%)
 1 9 (50.0) 4 (23.5) 13 (37.1)
 2 3 (16.7) 9 (52.9) 12 (34.3)
 3 4 (22.2) 3 (17.7) 7 (20.0)
 4 2 (11.1) 1 (5.9) 3 (8.6)
Time between surgery and recurrent radicular pain (days), median (IQR) 77.0 (46.0–142.0) 99.0 (91.0–153.0) 92.0 (61.0–153.0)
Time between last surgery and inclusion (years), median (IQR) 1.9 (1.4–3.0) 2.7 (1.8–4.5) 2.3 (1.6–3.6)
Co-interventions, n (%) 15 (83.3) 15 (88.2) 30 (85.7)
 Analgesics 14 (77.8) 15 (88.2) 29 (82.9)
  Grade 1 9 (50.0) 8 (47.1) 17 (48.6)
  Grade 2 12 (66.7) 11 (64.7) 23 (65.7)
  Grade 3 2 (11.1) 1 (5.9) 3 (8.6)
 Nonsteroidal anti-inflammatory drugs 5 (27.8) 5 (29.4) 10 (28.6)
 Corticosteroids 2 (11.1) 2 (11.8) 4 (11.4)
 Antidepressants 9 (50.0) 11 (64.7) 20 (57.1)
 Anxiolytics 3 (16.7) 3 (17.6) 6 (17.1)
 Antiepileptics 8 (44.4) 8 (47.1) 16 (45.7)
Retractile scar, n (%) 13 (72.2) 10 (58.8) 23 (65.7)
Nerve root enhancement, n (%) 14 (77.8) 11 (64.7) 25 (71.4)
Nerve root enlargement, n (%) 11 (61.1) 4 (23.5) 15 (42.9)
Arachnoiditis, n (%) 3 (16.7) 2 (11.8) 5 (14.3)
Modic 1 changes, n (%) 10 (55.6) 9 (52.9) 19 (54.3)
  1. BMI Body mass index, FAB-Q Fear Avoidance Beliefs Questionnaire, HAD-S Hospital Anxiety Depression Scale, IFX Infliximab, IQR Interquartile range, MRI Magnetic resonance, imaging, N Absolute frequency, VAS Visual analog scale