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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Twenty-eight-week results from the REALISTIC phase IIIb randomized trial: efficacy, safety and predictability of response to certolizumab pegol in a diverse rheumatoid arthritis population

Fig. 3

Clinical response at week 28, stratified by baseline characteristics. a Week 28 ACR20/ACR50/ACR70 responses stratified by prior anti-TNF therapy. b DAS28(CRP) progression up to week 28 by prior anti-TNF therapy. c Week 28 ACR20/ACR50/ACR70 responses stratified by baseline DMARDs. d Week 28 ACR20/ACR50/ACR70 responses stratified by disease duration (OL set, imputed data). Footnote: ACR response rates were calculated using NRI if withdrawal was due to an AE or lack/loss of efficacy, and LOCF in case of any other reason. Least squares mean (change from baseline) in DAS28(CRP) was analyzed using MMRM. AE adverse event, CRP C-reactive protein, CZP certolizumab pegol, DAS28 Disease Activity Score in 28 joints, LOCF last observation carried forward, MMRM mixed-effects model for repeated measures, NRI nonresponder imputation, OL open-label, TNF tumor necrosis factor

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Arthritis Research & Therapy

ISSN: 1478-6362

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