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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation

Fig. 7

Effect of Citral on renal levels of superoxide anion, cytoplasmic NAD(P)H oxidase subunit p47phox and cyclooxygenase-2 (COX-2), nuclear nuclear factor E2-related factor 2 (Nrf2), and serum prostaglandin E2 (PGE2) in mouse model. a Reactive oxygen species levels in renal tissues expressed as reactive luminescence units (RLU)/15 min/mg dry weight. b Representative western blots for cytosolic levels of p47phox and COX-2, with β-actin as the loading control. c and d Semiquantitative analysis of the p47phox/β-actin ratio (c) and the COX-2/β-actin ratio (d). e Serum PGE2 levels measured by ELISA. f Representative western blots for nuclear levels of Nrf2. with Lamin A as the loading control. g Semiquantitative analysis of the Nrf2/Lamin A ratio. Bars show mean ± standard error of the mean for 7 mice per group; *p <0.05, **p <0.01, and ***p <0.005. ASLN accelerated and severe lupus nephritis

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