TY - JOUR AU - Lowin, Torsten AU - Apitz, Martin AU - Anders, Sven AU - Straub, Rainer H. PY - 2015 DA - 2015/11/14 TI - Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner JO - Arthritis Research & Therapy SP - 321 VL - 17 IS - 1 AB - The endocannabinoid system modulates function of immune cells and mesenchymal cells such as fibroblasts, which contribute to cartilage destruction in rheumatoid arthritis (RA). The aim of the study was to determine the influence of N-acylethanolamines anandamide (AEA), palmitoylethanolamine (PEA) and oleylethanolamine (OEA) on several features of arthritic inflammation in vitro (human material) and in vivo (a mouse model). SN - 1478-6354 UR - https://doi.org/10.1186/s13075-015-0845-5 DO - 10.1186/s13075-015-0845-5 ID - Lowin2015 ER -