Skip to main content
Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner

Fig. 3

Influence of anandamide (AEA) on TNF-induced (10 ng/ml) IL-6 (a, b), IL-8 (c, d) and MMP-3 (e, f) production by RASF under hypoxic conditions. The dotted line indicates the control level of 100 % (TNF without AEA). ***p <0.001, for comparisons vs. control; p values for comparisons between AEA/A967079 and AEA/A967079/nimesulide are given in the graph. n.s., not significant. The general linear model with Dunnett’s post hoc test was used for all comparisons. All data are given as mean ± SEM. Cyclooxygenase-2 inhibitor = nimesulide, TRPA1 antagonist = A967079. IL-6 interleukin 6, IL-8 interleukin 8, MMP-3 matrix metalloproteinase 3 (stromelysin), RA rheumatoid arthritis, SF synovial fibroblast(s), TNF tumor necrosis factor, TRPA1 transient receptor potential ankyrin 1, TRPV1 transient receptor potential vanilloid channel

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us