Fig. 4

Influence of oleoylethanolamine (OEA) on TNF-induced IL-6 (a, b), IL-8 (c, d) and MMP-3 (e, f) production by RASF under hypoxic conditions. The dotted line indicates the control level of 100 % (TNF alone). ***p <0.001 for comparisons vs. control (TNF alone); p values for comparisons between OEA/A967079 and OEA/A967079/nimesulide or OEA/capsazepine/nimesulide are given in the graph. n.s., not significant. The general linear model with Dunnett’s post hoc test was used for all comparisons. All data are given as mean ± SEM. TRPV1 antagonist = capsazepine, TRPA1 antagonist = A967079, cyclooxygenase-2 inhibitor = nimesulide. IL-6 interleukin 6, IL-8 interleukin 8, MMP-3 matrix metalloproteinase 3 (stromelysin), RA rheumatoid arthritis, SF synovial fibroblast(s), TNF tumor necrosis factor, TRPA1 transient receptor potential ankyrin 1, TRPV1 transient receptor potential vanilloid channel