Fig. 6

Impact of anandamide on mitogen-activated protein kinase pathways in RASF. a-f Analysis of p38α phosphorylation (a, b), ERK1/2 phosphorylation (c, d) and cJun phosphorylation (e, f) under TNF treatment with or without AEA pretreatment under normoxic (a, c, e) and hypoxic (b, d, f) conditions. Paired t test was used for comparisons. Number of patients included was n = 4 (a, c, e) and n = 5 (b, d, f). AEA anandamide, RA rheumatoid arthritis, SF synovial fibroblast(s), TNF tumor necrosis factor