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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner

Fig. 7

Influence of anandamide (AEA) on proliferation and adhesion of OASF and RASF and collagen-induced arthritis in mice. (a-d) Impact of AEA on OASF (a, b) and RASF (c, d) proliferation under normoxic (a, c) and hypoxic (b, d) conditions. e, f Adhesion of RASF and OASF to fibronectin after 24 h treatment with AEA (e) or with AEA + CP945598 (f) under normoxic conditions. g Impact of FAAH inhibition on collagen-induced arthritis in mice. The general linear model with Dunnett’s post hoc test was used for all comparisons. All data are given as mean ± SEM. Nimesulide = cyclooxygenase-2 inhibitor, URB597 = covalent, irreversible FAAH inhibitor, CB1 antagonist = CP945598 =, covalent, reversible FAAH inhibitor = JNJ1661010. All antagonists/inhibitors (a-f) were used at [c] = 1 μM. FAAH fatty acid amide hydrolase, OA osteoarthritis, RA rheumatoid arthritis, SF synovial fibroblast(s)

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