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Table 1 Demographic and clinical characteristics of the groups studied

From: Serum leptin and serum leptin/serum leptin receptor ratio imbalance in obese rheumatoid arthritis patients positive for anti-cyclic citrullinated peptide antibodies

 

Normal weight

 

Preobese

 

Obese

 

Measurement

Control

RA

P

Control

RA

P

Control

RA

P

n = 21

n = 21

n = 26

n = 21

n = 19

n = 22

Age, years

34 ± 11

39 ± 12

0.127

43 ± 12

47 ± 10

0.230

46 ± 9

41 ± 9

0.076

Body weight, kg

60 ± 7

57 ± 6

0.126

68 ± 6

69 ± 5

0.578

91 ± 18

82 ± 9

0.060

BMI, kg/m2

22.00 ± 1.78

22.13 ± 2.27

0.845

27.26 ± 1.16

27.50 ± 1.28

0.498

35.03 ± 6.79

33.55 ± 2.75

0.384

Body fat mass, %

26.36 ± 5.66

25.95 ± 6.79

0.834

36.20 ± 3.24

36.21 ± 3.21

0.991

38.78 ± 8.19

42.35 ± 5.00

0.095

Body fat mass, kg

15.86 ± 3.87

14.67 ± 4.29

0.353

24.54 ± 4.84

24.88 ± 3.24

0.784

35.58 ± 12.01

34.81 ± 7.17

0.806

Body fat ratio, kg/m2

5.83 ± 1.47

5.80 ± 1.83

0.958

9.94 ± 1.54

9.97 ± 1.15

0.942

13.86 ± 5.25

14.29 ± 2.60

0.739

VFA, cm2

46.38 ± 26.58

77.12 ± 43.28

0.021

81.26 ± 23.62

119.52 ± 35.22

<0.001

106.43 ± 30.24

131.83 ± 21.97

0.036

S4ST, mm

52.08 ± 13.67

49.17 ± 14.48

0.513

105.94 ± 20.79

70.56 ± 19.21

<0.001

90.06 ± 16.94

76.34 ± 23.01

0.015

ESR, mm/h

9.76 ± 6.32

19.38 ± 9.82

0.001

21.19 ± 10.08

17.10 ± 12.14

0.213

14.21 ± 10.20

27.33 ± 14.08

<0.001

CRP, mg/L

5.22 ± 2.72

7.66 ± 7.08

0.153

3.56 ± 3.07

8.83 ± 6.67

0.005

8.66 ± 4.70

11.02 ± 9.19

0.112

Glucose mg/dL

94.43 ± 14.03

96.90 ± 14.27

0.574

93.42 ± 27.18

100.80 ± 16.33

0.223

101.37 ± 11.36

98.25 ± 10.81

0.386

Insulin, μΙU/mL

6.97 ± 6.97

14.43 ± 10.82

0.005

9.98 ± 6.56

14.76 ± 16.54

0.268

12.81 ± 8.35

23.16 ± 44.60

0.240

HOMA-IR

1.49 ± 1.16

3.61 ± 2.98

0.003

2.34 ± 1.59

4.34 ± 4.98

0.171

3.28 ± 2.25

5.58 ± 10.92

0.278

Leptin, ng/mL

30.14 ± 20.69

45.98 ± 40.26

0.119

35.48 ± 12.32

121.65 ± 106.35

0.001

79.11 ± 45.20

188.21 ± 100.88

<0.001

sLepR, ng/mL

68.81 ± 24.02

60.02 ± 18.81

0.209

43.98 ± 15.24

51.34 ± 12.51

0.131

44.75 ± 14.91

37.49 ± 9.67

0.096

Leptin/sLepR

0.53 ± .50

0.98 ± 1.40

0.176

0.89 ± 0.41

2.45 ± 2.45

0.033

2.18 ± 1.62

5.67 ± 3.56

0.002

Leptin/FM, ng/mL/kg

1.87 ± 1.21

3.04 ± 1.95

0.027

1.41 ± 0.423

4.99 ± 4.48

0.002

2.18 ± 1.19

5.32 ± 2.67

<0.001

sLepR/FM, ng/mL/kg

4.59 ± 1.89

4.56 ± 2.33

0.964

1.83 ± 0.71

2.12 ± 0.53

0.196

1.49 ± 0.95

1.10 ± 0.41

0.113

  1. Continuous variables are represented by mean ± standard deviation; means were compared with Student’s t test. RA rheumatoid arthritis, BMI body mass index, VFA visceral fat area, S4AP sum of four skinfold thicknesses (bicipital, tricipital, subscapular and supra-iliac), ESR erythrocyte sedimentation rate, CRP C-reactive protein, sLepR soluble leptin receptor), FM fat mass, HOMA-IR homeostatic model assessment-insulin resistance
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Arthritis Research & Therapy

ISSN: 1478-6362

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