Table 2 Validation of top SNP rs5914778 in southern and northern regions of China
From: Discovery of a novel genetic susceptibility locus on X chromosome for systemic lupus erythematosus
Central meta (discovery + central validation)a | Southern validationb | Northern validationc | Meta (discovery + central + southern validations)d | Meta (discovery + central + southern + northern validations)e | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Marker | Gene symbol | PVAL (FE) | OR (FE) | PVAL | OR | MAF (case) | MAF (control) | PVAL | OR | MAF (case) | MAF (control) | PVAL (FE) | I 2 (FE) | PVAL (Het) | OR (FE) | PVAL (FE) | I 2 (FE) | PVAL (Het) | OR (FE) |
rs5914778 | LINC01420 | 1.00 × 10–8 | 1.32 | 5.31 × 10–5 | 1.51 | 0.352 | 0.265 | 3.28 × 10–1 | 0.85 | 0.252 | 0.284 | 5.26 × 10–12 | 0 | 4.62 × 10–1 | 1.35 | 1.22 × 10–10 | 65.3 | 3.44 × 10–2 | 1.31 |