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Table 2 Validation of top SNP rs5914778 in southern and northern regions of China

From: Discovery of a novel genetic susceptibility locus on X chromosome for systemic lupus erythematosus

Central meta (discovery + central validation)a Southern validationb Northern validationc Meta (discovery + central + southern validations)d Meta (discovery + central + southern + northern validations)e
Marker Gene symbol PVAL (FE) OR (FE) PVAL OR MAF (case) MAF (control) PVAL OR MAF (case) MAF (control) PVAL (FE) I 2 (FE) PVAL (Het) OR (FE) PVAL (FE) I 2 (FE) PVAL (Het) OR (FE)
rs5914778 LINC01420 1.00 × 10–8 1.32 5.31 × 10–5 1.51 0.352 0.265 3.28 × 10–1 0.85 0.252 0.284 5.26 × 10–12 0 4.62 × 10–1 1.35 1.22 × 10–10 65.3 3.44 × 10–2 1.31
  1. aConsists of 2173 cases and 2869 controls
  2. bConsists of 1012 cases and 335 controls
  3. cConsists of 274 cases and 133 controls
  4. dConsists of 3185 cases and 3204 controls
  5. eConsists of 3459 cases and 3337 controls
  6. FE fixed effects, Het heterogeneity, I 2 heterogeneity statistic, MAF minor allele frequency, OR odds ratio, PVAL P value, SNP single nucleotide polymorphism