Fig. 1

Joint swelling and pain-related behaviors in SNS-gp130^flox/flox and SNS-gp130^−/− mice after induction of AIA. a. In acute primary AIA SNS-gp130^−/− mice (n = 16) show significantly less joint swelling than SNS-gp130^flox/flox mice (n = 19) (F[1, 33] = 9.476; p = 0.004). b. The same effect was observed in the flare-up reaction (induced 21 days after the primary AIA) up to day 7 (F[1, 19] = 8.438; p = 0.009; n = 10–11 per group). c. Reduction of mechanical withdrawal threshold at the paw ipsilateral to the inflamed knee and increase in threshold at the paw contralateral to the inflamed knee in SNS-gp130^flox/flox mice (F[1, 11] = 28.298; p < 0.001). d. No significant differences between the ipsilateral and contralateral paw in SNS-gp130^−/− mice after AIA induction (F[1, 13] = 0.713; p = 0.414). In c and d: n = 6–8 per group. e. Areas between the ipsilateral and contralateral curves in c and d. Values are mean ± SEM, *p < 0.05, **p < 0.01. AIA antigen-induced arthritis, AUC area under the curve, BL baseline