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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Interleukin-6-dependent influence of nociceptive sensory neurons on antigen-induced arthritis

Fig. 2

Histopathological scores of AIA in SNS-gp130−/− and SNS-gp130flox/flox mice. a. Scores of synovitis and damage to articular cartilage or bone in both groups of mice at day 3 of primary AIA. b. Scores of inflammation and destruction in both groups of mice at day 12 of flare-up. Values in a and b are mean ± SEM. c. Correlation between joint swelling and histopathological arthritis score in SNS-gp130flox/flox mice (solid line, r = 0.831, p = 0.002) and SNS-gp130−/− mice (broken line, r = 0.267, p = 0.457), n = 10–11 per group. d. Representative pictures (100×) of H&E-stained knee joint sections from SNS-gp130flox/flox and SNS-gp130−/− mice at day 3 of AIA. AIA antigen-induced arthritis, F femur, M meniscus, SL synovial layer, T tibia,

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