Fig. 2

Histopathological scores of AIA in SNS-gp130^−/− and SNS-gp130^flox/flox mice. a. Scores of synovitis and damage to articular cartilage or bone in both groups of mice at day 3 of primary AIA. b. Scores of inflammation and destruction in both groups of mice at day 12 of flare-up. Values in a and b are mean ± SEM. c. Correlation between joint swelling and histopathological arthritis score in SNS-gp130^flox/flox mice (solid line, r = 0.831, p = 0.002) and SNS-gp130^−/− mice (broken line, r = 0.267, p = 0.457), n = 10–11 per group. d. Representative pictures (100×) of H&E-stained knee joint sections from SNS-gp130^flox/flox and SNS-gp130^−/− mice at day 3 of AIA. AIA antigen-induced arthritis, F femur, M meniscus, SL synovial layer, T tibia,