Fig. 8

Cytokine expression profiles of lymphocytes from naïve SNS-gp130^flox/flox and SNS-gp130^−/− mice. Levels of (a) IL-2, (b) IL-17 and (c) IFNγ in supernatants of unstimulated (w/o) or anti-CD3-stimulated spleen cells. Additionally, cells were preincubated for 1 h with CGRP (100 nM or 10 pM) and/or IL-6/sIL-6R (90 ng/ml) before anti-CD3 stimulation. Values (mean ± SEM) are given as absolute concentrations (pg/ml or ng/ml) or as changes against cytokine concentration of anti-CD3 stimulation (baseline) in %. *p < 0.05 compared to baseline, by Wilcoxon’s matched-pairs signed-rank test. n = 6 per group. CGRP calcitonin gene-related peptide, IFNγ interferon-γ, IL interleukin sIL-6R soluble IL-6 receptor