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Table 1 The test characteristics of different autoantibodies in RA

From: The specificity of anti-carbamylated protein antibodies for rheumatoid arthritis in a setting of early arthritis

  Sensitivity Specificity PPV NPV LR+ LR–
Anti-CarP 44 % 89 % 78 % 65 % 4.2 0.62
Anti-CCP2 54 % 96 % 94 % 64 % 12.9 0.48
IgM-RF 59 % 91 % 86 % 72 % 6.9 0.44
Anti-CarP in anti-CCP-negative patient 12 % 91 % 37 % 71 % 1.3 0.97
  1. A comparison is provided on the test characteristics of anti-CarP, anti-CCP and IgM RF for diagnosing RA. In addition the performance of anti-CarP in the CCP2-negative stratum is analyzed
  2. Anti-CarP Anti-carbamylated protein, Anti-CCP2 Anti-cyclic citrullinated peptide 2, IgM-RF Immunoglobulin M-rheumatoid factor, LR+ Positive likelihood ratio, LR– Negative likelihood ratio, NPV Negative predictive value, PPV Positive predictive value, RA Rheumatoid arthritis