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Table 1 Clinical and demographic characteristics of RA patients prior to pneumococcal vaccination

From: Effect of abatacept on the immunogenicity of 23-valent pneumococcal polysaccharide vaccination (PPSV23) in rheumatoid arthritis patients

 

RA control

MTX group

ABT group

p Values between treatment groups

n = 35

n = 55

n = 21

Male/female

12/23

11/44

4/17

0.251

Age, mean ± SD (years)

70.5 ± 10.8

63.8 ± 11.5

59.8 ± 12.0

0.002

Weight, mean ± SD (Kg)

53.3 ± 9.5

52.9 ± 11.8

55.2 ± 10.1

0.501

BMI, mean ± SD

21.8 ± 3.5

21.7 ± 3.7

23.2 ± 4.9

0.344

RA duration, mean ± SD (years)

11.7 ± 12.5

14.1 ± 10.9

13.5 ± 11.2

0.144

MTX dose, mean ± SD (mg/week)

-

7.8 ± 2.4

7.2 ± 3.4(15/21)

-

ABT dose, mean ± SD (mg/4 week)

-

-

547.6 ± 127.9

-

Use of prednisolone, number of patients (%)

21 (60.0)

30 (54.5)

13(61.9)

0.798

Prednisolone dose, mean ± SD (mg/day)

6.06 ± 4.23

4.98 ± 2.97

5.04 ± 2.85

0.769

DAS28(CRP), mean ± SD

2.79 ± 1.17

2.61 ± 0.98

2.48 ± 1.31

0.565

SDAI, mean ± SD

9.03 ± 6.32

8.15 ± 7.33

8.32 ± 7.29

0.593

CDAI, mean ± SD

7.83 ± 5.40

7.46 ± 6.73

7.87 ± 6.54

0.721

IP (%)

6 (17.1)

7 (12.7)

3(14.3)

0.844

COPD (%)

3 (8.6)

1 (1.8)

2(9.5)

0.251

Smoking history (%)

10(28.6)

13(23.6)

6(28.6)

0.839

  1. Data were obtained immediately before pneumococcal vaccination. p values between treatment groups were determined using the Kruskal-Wallis test. p values were calculated with the chi-square test for qualitative data. RA rheumatoid arthritis, MTX methotrexate, ABT abatacept, BMI body mass index, DAS28 Disease Activity Score 28, SDAI simplified disease activity index, CDAI clinical disease activity index, IP interstitial pneumonia, COPD chronic obstructive pulmonary disease