Fig. 7

Subchondral bone changes analyzed with longitudinal in vivo micro–computed tomography (μCT) in untreated animals (circles) and triamcinolone acetonide–treated animals (squares). Subchondral plate thickness (Sb. Pl. Th.; a and c) and porosity (Sb. Pl. Por.; b and d) were measured in the medial (a and b) and lateral (c and d) compartments of the tibial epiphysis. Changes in trabecular thickness (Tb. Th.; e) and trabecular bone volume fraction (BV/TV; f) were measured in tibial epiphysis bone marrow. g and h Representative sagittal images from binary μCT scans show pore development (indicated with inverted triangles) and development of subchondral sclerosis (indicated with dashed lines and asterisks) in the medial (g) and lateral (h) compartments of the tibial epiphysis. *p < 0.05, **p < 0.01, ***p < 0.001. Error bars indicate 95 % confidence intervals. OA osteoarthritis