TY - JOUR AU - Infantino, Maria AU - Meacci, Francesca AU - Grossi, Valentina AU - Benucci, Maurizio AU - Morozzi, Gabriella AU - Tonutti, Elio AU - Tampoia, Marilina AU - Ott, Antonina AU - Meyer, Wolfgang AU - Atzeni, Fabiola AU - Sarzi-Puttini, Piercarlo AU - Manfredi, Mariangela AU - Bizzaro, Nicola PY - 2015 DA - 2015/12/17 TI - Serological epitope profile of anti-Ro52–positive patients with systemic autoimmune rheumatic diseases JO - Arthritis Research & Therapy SP - 365 VL - 17 IS - 1 AB - Ro52 is an interferon-inducible protein of the tripartite motif family. Antibodies against Ro52 have been described in patients with different autoimmune diseases, such as systemic lupus erythematosus and Sjögren’s syndrome, that are often associated with anti-Ro60 antibodies. The Ro52 autoantigen is extraordinarily immunogenic, and its autoantibodies are directed against both linear and conformational epitopes. The aim of this study was to evaluate the prevalence of antibodies to the five Ro52 domains, as well as to Ro52 176– to 196–amino acid (aa) and 200–239-aa peptides, in different systemic autoimmune rheumatic diseases (SARDs). We also aimed to verify whether antibodies to a single domain or domain association could increase their diagnostic specificity for any SARD. SN - 1478-6354 UR - https://doi.org/10.1186/s13075-015-0871-3 DO - 10.1186/s13075-015-0871-3 ID - Infantino2015 ER -