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Table 3 Multivariate logistic regression analysis for variables associated with musculoskeletal pain alone and combined with increased pain sensitivity among females

From: A low cortisol response to stress is associated with musculoskeletal pain combined with increased pain sensitivity in young adults: a longitudinal cohort study

 

MS pain only

MS pain combined with CPT > P50a

MS pain combined with PPT < P50a

 

Any pain

High pain problem severityb

Any pain

High pain problem severityb

Any pain

High pain problem severityb

Cortisol response group

      

 Cluster 1

1.5 (0.8–2.8)

1.8 (0.9–3.7)

2.3 (1.0–5.0)c

2.8 (1.1–6.8)c

2.2 (1.0–4.8)

3.5 (1.3–9.7)c

 Cluster 2

1.0

1.0

1.0

1.0

1.0

1.0

 Cluster 3

0.6 (0.3–1.4)

1.1 (0.4–2.8)

0.9 (0.3–2.7)

1.5 (0.4–5.5)

0.8 (0.3–2.6)

1.7 (0.3–8.2)

Oral contraceptive use

      

 No

1.0

1.0

1.0

1.0

1.0

1.0

 Yes

1.3 (0.7–2.5)

1.0 (0.5–2.1)

0.8 (0.4–2.0)

0.6 (0.2–1.8)

0.8 (0.3–1.9)

0.4 (0.1–1.4)

Smoking

      

 No

1.0

1.0

1.0

1.0

1.0

1.0

 Yes

0.9 (0.3–2.9)

1.6 (0.5–5.3)

0.7 (0.1–3.6)

1.1 (0.2–6.2)

0.2 (0.0–1.9)

0.7 (0.1–6.7)

Body mass index

      

 Normal

1.0

1.0

1.0

1.0

1.0

1.0

 Overweight

1.2 (0.6–2.6)

1.3 (0.6–2.9)

0.6 (0.2–1.6)

0.7 (0.2–2.2)

0.4 (0.1–1.3)

0.9 (0.3–3.1)

 Obese

1.3 (0.4–3.6)

0.6 (0.2–1.9)

0.7 (0.2–2.5)

0.4 (0.1–2.1)

0.6 (0.2–2.3)

0.2 (0.0–2.0)

Physical activity level

      

 0 h/wk

1.0

1.0

1.0

1.0

1.0

1.0

 0.1–4.9 h/wk

1.1 (0.6–2.1)

1.3 (0.6–2.5)

1.0 (0.5–2.1)

1.1 (0.4–2.5)

0.7 (0.3–1.5)

0.6 (0.2–1.7)

  ≥ 5.0 h/wk

0.8 (0.4–1.6)

0.8 (0.3–2.0)

0.5 (0.2–1.3)

0.7 (0.2–2.0)

0.3 (0.1–0.8)

0.3 (0.1–1.2)

Depressive symptoms

      

 Minimal

1.0

1.0

1.0

1.0

1.0

1.0

 Mild

1.8 (0.9–3.9)

1.7 (0.7–3.7)

2.0 (0.8–4.8)

1.9 (0.7–5.2)

2.0 (0.8–5.0)

1.0 (0.3–3.5)

 Moderate to severe

1.3 (0.5–3.0)

1.7 (0.7–4.3)

0.7 (0.2–2.1)

0.8 (0.2–2.9)

0.9 (0.3–2.6)

0.6 (0.2–2.5)

  1. MS musculoskeletal, CPT cold pain threshold, PPT pressure pain threshold
  2. Data are presented as odds ratios with 95 % confidence intervals
  3. aMedian (P50) CPT = 15 °C; median PPT = 318 kPa
  4. bHigh pain problem severity index = 15 or more
  5. c p < 0.05
  6. All covariates were included in the multivariate model. Reference group includes those without pain or with a low severity of pain and those with pain but with CPT < P50 or PPT > P50
  7. The number of individuals included in the analysis varied from 198 to 222 due to missing data