|
MS pain only
|
MS pain combined with CPT > P50a
|
MS pain combined with PPT < P50a
|
---|
|
Any pain
|
High pain problem severityb
|
Any pain
|
High pain problem severityb
|
Any pain
|
High pain problem severityb
|
---|
Cortisol response group
| | | | | | |
Cluster 1
|
0.7 (0.3–1.5)
|
0.6 (0.3–1.5)
|
1.2 (0.4–3.3)
|
1.6 (0.5–4.9)
|
1.5 (0.6–4.1)
|
1.7 (0.6–4.9)
|
Cluster 2
|
1.0
|
1.0
|
1.0
|
1.0
|
1.0
|
1.0
|
Cluster 3
|
0.9 (0.4–1.8)
|
0.8 (0.3–1.8)
|
1.0 (0.4–2.9)
|
1.2 (0.3–3.9)
|
2.1 (0.9–5.4)
|
2.1 (0.7–5.9)
|
Smoking
| | | | | | |
No
|
1.0
|
1.0
|
1.0
|
1.0
|
1.0
|
1.0
|
Yes
|
1.1 (0.4–2.8)
|
1.7 (0.6–4.4)
|
0.2 (0.0–1.9)
|
0.3 (0.0–2.9)
|
0.6 (0.1–2.8)
|
0.7 (0.2–3.7)
|
Body mass index
| | | | | | |
Normal
|
1.0
|
1.0
|
1.0
|
1.0
|
1.0
|
1.0
|
Overweight
|
1.5 (0.7–3.0)
|
1.8 (0.8–3.8)
|
0.9 (0.3–2.6)
|
1.1 (0.4–3.6)
|
0.7 (0.3–2.0)
|
1.0 (0.3–3.1)
|
Obese
|
1.7 (0.5–6.2)
|
2.9 (0.8–10.8)
|
1.1 (0.1–9.5)
|
1.6 (0.2–15.8)
|
1.5 (0.3–7.7)
|
2.2 (0.4–11.7)
|
Physical activity level
| | | | | | |
0 h/wk
|
1.0
|
1.0
|
1.0
|
1.0
|
1.0
|
1.0
|
0.1–4.9 h/wk
|
0.7 (0.3–1.4)
|
0.4 (0.2–1.0)
|
0.4 (0.1–1.3)
|
0.3 (0.1–1.2)
|
0.8 (0.3–2.1)
|
0.6 (0.2–1.8)
|
≥ 5.0 h/wk
|
1.0 (0.5–2.1)
|
0.8 (0.4–1.8)
|
0.8 (0.3–2.0)
|
0.8 (0.3–2.4)
|
0.8 (0.3–2.1)
|
0.9 (0.3–2.5)
|
Depressive symptoms
| | | | | | |
Minimal
|
1.0
|
1.0
|
1.0
|
1.0
|
1.0
|
1.0
|
Mild
|
1.4 (0.5–4.2)
|
1.6 (0.5–4.9)
|
3.1 (0.9–10.8)
|
3.3 (0.9–12.8)
|
1.4 (0.3–5.5)
|
1.8 (0.4–7.5)
|
Moderate to severe
|
4.2 (1.0–17.9)
|
3.7 (0.9–15.3)
|
1.2 (0.1–10.9)
|
1.5 (0.2–15.2)
|
0.7 (0.1–6.4)
|
0.9 (0.1–8.4)
|
-
MS musculoskeletal, CPT cold pain threshold, PPT pressure pain threshold
- Data are presented as odds ratios with 95 % confidence intervals
-
aMedian (P50) CPT = 7 °C; median PPT = 419 kPa
-
bHigh pain problem severity index = 9 or more
- All covariates were included in the multivariate model. Reference group includes those without pain or with a low severity of pain and those with pain but with CPT < P50 or PPT > P50
- The number of individuals included in the analysis varied from 198 to 215 due to missing data