Fig. 1
From: Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult
Schematic of experimental design. Studies 1 through 3 utilized the well-established juvenile bovine model system. Study 1 examined the protection afforded by low-dose IL-1α exposure. Study 2 investigated the time-dependent effects of preconditioning on protection by applying an immediate and delayed insult. Study 3 examined the effect of CoCl2 preconditioning to investigate a potential mechanism of protection. Study 4 explored the translational potential of preconditioning schemes by characterizing the effect on clinically relevant adult passaged canine chondrocytes. CoCl 2 cobalt chloride, IL-1 interleukin-1