TY - JOUR AU - Lenna, Stefania AU - Assassi, Shervin AU - Farina, G. Alessandra AU - Mantero, Julio C. AU - Scorza, Raffaella AU - Lafyatis, Robert AU - Farber, Harrison W. AU - Trojanowska, Maria PY - 2015 DA - 2015/12/16 TI - The HLA-B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients JO - Arthritis Research & Therapy SP - 363 VL - 17 IS - 1 AB - HLA-B*35 is associated with increased risk of developing pulmonary hypertension in SSc patients. We previously reported that HLA-B*35 induces endothelial cell dysfunction via activation of ER stress/UPR and upregulation of the inflammatory response. Because PBMCs from lcSSc-PAH patients are also characterized by activation of ER stress/UPR and inflammation, the goal of this study was to assess whether the presence of HLA-B*35 contributes to those characteristics. SN - 1478-6354 UR - https://doi.org/10.1186/s13075-015-0881-1 DO - 10.1186/s13075-015-0881-1 ID - Lenna2015 ER -