TY - JOUR AU - Yang, Tao-Hsiang AU - Hsu, Peng-Yang AU - Meng, Menghsiao AU - Su, Che-Chun PY - 2015 DA - 2015/12/15 TI - Supplement of 5-hydroxytryptophan before induction suppresses inflammation and collagen-induced arthritis JO - Arthritis Research & Therapy SP - 364 VL - 17 IS - 1 AB - Evidence is accumulating that a preclinical phase is present before the onset of clinical signs and symptoms of rheumatoid arthritis (RA). This phase represents an important therapeutic window within which interventions can dramatically modulate outcomes. An agent able to prevent RA for high risk individuals in this phase is therefore desired. In this study, we investigated whether tryptophan metabolite, 5-hydroxytryptophan (5-HTP) or 5-methoxytryptophan (5-MTP), can act as such an agent for primary prevention of collagen-induced arthritis (CIA). SN - 1478-6354 UR - https://doi.org/10.1186/s13075-015-0884-y DO - 10.1186/s13075-015-0884-y ID - Yang2015 ER -