TY - JOUR AU - Thompson, Clare L. AU - Patel, Riana AU - Kelly, Terri-Ann N. AU - Wann, Angus K. T. AU - Hung, Clark T. AU - Chapple, J. Paul AU - Knight, Martin M. PY - 2015 DA - 2015/12/24 TI - Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β JO - Arthritis Research & Therapy SP - 373 VL - 17 IS - 1 AB - In osteoarthritis, chondrocytes adopt an abnormal hypertrophic morphology and upregulate the expression of the extracellular matrix-degrading enzymes, MMP-13 and ADAMTS-5. The activation of the hedgehog signalling pathway has been established in osteoarthritis and is thought to influence both of these processes. However, the role of this pathway in the initiation and progression of osteoarthritis is unclear as previous studies have been unable to isolate the effects of hedgehog pathway activation from other pathological processes. In this study we test the hypothesis that hedgehog pathway activation causes cartilage degradation in healthy cartilage and in an in vitro model of inflammatory arthritis. SN - 1478-6362 UR - https://doi.org/10.1186/s13075-015-0891-z DO - 10.1186/s13075-015-0891-z ID - Thompson2015 ER -