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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β

Fig. 5

IL-1β reduces hedgehog pathway activation in response to recombinant Indian hedgehog (r-Ihh). After 24 hours of treatment, in bovine articular chondrocytes, IL-1β prevents upregulation in GLI1 (a) and PTCH1 (b) expression in response to r-Ihh treatment. c Treatment with IL-1β similarly repressed r-Ihh upregulation of a disintegrin and matrix metalloproteinase with thrombospondin motif (ADAMTS-5) expression but did not completely abolish this effect. *Statistically significant difference between the r-Ihh-treated samples and the untreated control; +statistically significant difference between the r-Ihh/IL-1β-treated samples and the r-Ihh-treated samples (n = 9 from three separate donors), ***P ≤0.001, ++ P ≤0.01, and +++ P ≤0.001

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