Table 3 Performance characteristics of biomarkers to detect clinical response in SLE (reduction in ECLAM score of 3 or more)
Spearman correlation | Mixed-effects | ROC curve analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|
Biomarker | r value | P value | P value | AUC (95 % CI) | Youden index | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
∆sVCAM-1 | 0.622 | 9.7 × 10−10 | 3.9 × 10−9 | 0.899 (0.808 − 0.968) | 0.703 | 86.4 | 83.9 | 67.9 | 94.0 |
∆sICAM-1 | 0.357 | 0.0012 | 3.4 × 10−5 | 0.688 (0.537 − 0.824) | 0.426 | 72.7 | 69.9 | 48.5 | 86.7 |
∆sE-selectin | 0.162 | NS | 1.0 × 10−4 | 0.569 (0.382 − 0.737) | 0.338 | 40.9 | 92.9 | 69.2 | 80.0 |
∆sP-selectin | −0.092 | NS | NS | 0.541 (0.385 − 0.692) | 0.287 | 59.1 | 69.6 | 43.3 | 81.2 |
∆ESR | 0.211 | 0.062 | 8.3 × 10−5 | 0.586 (0.417 − 0.738) | 0.302 | 40.9 | 89.3 | 60.0 | 79.4 |
∆dsDNA | 0.292 | 0.0085 | 0.052 | 0.731 (0.581 − 0.860) | 0.550 | 81.8 | 73.2 | 54.5 | 91.1 |
∆C3 | −0.367 | 8.0 × 10−4 | 2.9 × 10−4 | 0.772 (0.634 − 0.890) | 0.639 | 81.8 | 82.1 | 64.3 | 92.0 |
∆C4 | −0.274 | 0.014 | NS | 0.689 (0.543− 0.821) | 0.406 | 72.7 | 67.9 | 47.1 | 86.4 |