TY - JOUR AU - Lim, Ngee Han AU - Vincent, Tonia L. AU - Nissim, Ahuva PY - 2015 DA - 2015/12/25 TI - In vivo optical imaging of early osteoarthritis using an antibody specific to damaged arthritic cartilage JO - Arthritis Research & Therapy SP - 376 VL - 17 IS - 1 AB - The lack of specific and sensitive serum and radiographic biomarkers for early diagnosis of osteoarthritis (OA) as well as for monitoring subtle changes in disease activity in clinical trials has hampered the development of treatments for OA. We previously showed that 1-11E, a human single chain fragment variable (scFv) specific to collagen type II that has been post-translationally modified by reactive oxidants (ROS-CII), binds exclusively to arthritic cartilage. Here we test the validity of 1-11E as a radiographic biomarker for early disease in experimental OA. SN - 1478-6362 UR - https://doi.org/10.1186/s13075-015-0898-5 DO - 10.1186/s13075-015-0898-5 ID - Lim2015 ER -