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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Soluble biglycan: a potential mediator of cartilage degradation in osteoarthritis

Fig. 4

Effects of soluble biglycan (sBGN) on release of glycosaminoglycans (GAGs) and soluble collagen from cartilage explants compared with non-stimulated controls. a In grade I osteoarthritis (OA), sBGN increased GAG release. b In grade IV OA, sBGN increased collagen release. The results are presented as mean ± SD. Samples were run as technical duplicates, and each experiment was done using samples from at least six different donors (biological replicates). *p < 0.05 vs. non-stimulated controls; ## p < 0.01 for pairwise comparisons between mild grade I OA and severe grade IV OA

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