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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Soluble biglycan: a potential mediator of cartilage degradation in osteoarthritis

Fig. 5

Effects of soluble biglycan (sBGN) on proteoglycan content in osteoarthritis (OA) cartilage explants from five different patients. a Safranin O staining of the formalin-fixed, paraffin-embedded tissue sections produced from the OA cartilage explants (4 mm) after 48-h incubation. Note extensive proteoglycan depletion in all samples. Safranin O photomicrographs are panoramic images constructed from several photomicrographs to provide an overall view of cartilage explant extent in one image. Original magnification, ×20. b Proteoglycan depletion was quantified by optical density of Safranin O staining using ImageJ image analysis software. The results are presented as mean ± SD. Proteoglycan content was reduced by 50 ± 20 % compared with non-stimulated samples. **p < 0.01

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