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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Soluble biglycan: a potential mediator of cartilage degradation in osteoarthritis

Fig. 6

Effect of soluble biglycan (sBGN) on expression of Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) on primary chondrocytes. a In primary chondrocytes, sBGN increased TLR4 (p < 0.05) and did it as effectively as lipopolysaccharide (LPS), which was used as a positive control. b In cartilage explants, sBGN increased TLR4, both in mild grade I (p < 0.05) and in severe grade IV (p < 0.05) osteoarthritis (OA), but differently in mild and severe OA. The results are expressed as fold changes (mean ± SD) relative to TATA box-binding protein (TBP) housekeeper and compared with non-stimulated controls, which corresponds to a fold change of 1. Samples were run as technical duplicates, and each experiment was done using samples obtained from at least six different donors (biological replicates). *p < 0.05 vs. non-stimulated controls; ## p < 0.01 for pairwise comparisons between mild grade I OA and severe grade IV OA

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