Fig. 1

Nociceptive thresholds and weight-bearing distribution in mice with CFA-induced mono-arthritis maintained either at RT or exposed to cold (10 °C) for 1 h prior to measurements. a Secondary thermal hyperalgesia (using Hargreaves test). b Secondary mechanical hyperalgesia (using dynamic plantar aesthesiometer). c Weight bearing (using incapacitance tester). Measurements were taken before (baseline) and 2 weeks after mono-arthritis induction. n = 6 ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001 compared to baseline, using repeated measures two-way ANOVA and Bonferroni’s multiple comparisons. CFA complete Freund’s adjuvant, RT room temperature