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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner

Fig. 1

Nociceptive thresholds and weight-bearing distribution in mice with CFA-induced mono-arthritis maintained either at RT or exposed to cold (10 °C) for 1 h prior to measurements. a Secondary thermal hyperalgesia (using Hargreaves test). b Secondary mechanical hyperalgesia (using dynamic plantar aesthesiometer). c Weight bearing (using incapacitance tester). Measurements were taken before (baseline) and 2 weeks after mono-arthritis induction. n = 6 * p < 0.05, ** p < 0.01, *** p < 0.001 compared to baseline, using repeated measures two-way ANOVA and Bonferroni’s multiple comparisons. CFA complete Freund’s adjuvant, RT room temperature

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