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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner

Fig. 3

Effect of cold exposure on knee joint blood flow in animals with CFA-induced mono-arthritis. Mono-arthritis was induced in animals by injection of CFA (ipsilateral joint) and saline (contralateral joint). a FLPI images of blood flow in the recorded regions of interest from the synovial membrane in naïve and arthritic animals following 1 h exposure to RT or cold (10 °C) 2 weeks after CFA injection. b Average blood flow measured using FLPI in joints of naïve and arthritic animals at RT or exposed to cold, n = 7–8, * p < 0.05 compared to cold-exposed CFA-treated joint, # p < 0.05 compared to cold-exposed naïve and saline-treated joints. c Percentage clearance of 99mTechnetium in the knee joint after 5 min in arthritic animals at RT or exposed to cold, n = 7, * p < 0.05 compared with saline-treated counterparts. CFA complete Freund’s adjuvant, FLPI full-field laser perfusion imager, RT room temperature

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