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Table 1 mRNA expression in arthritic mice exposed to cold

From: Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner

Gene Tissue RT 10 °C
   Saline CFA Saline CFA
TRPA1 DRG 862.76 ± 62.84 1116.79 ± 109.20 1005.35 ± 98.58 879.87 ± 63.95
TRPA1 Synovial membrane 24.17 ± 5.48 20.09 ± 5.41 31.98 ± 6.98 7.69 ± 0.98*
TRPA1 Patellar cartilage 41.20 ± 8.21 48.94 ± 10.15 45.56 ± 8.14 115.00 ± 42.37*#
TAC-1 DRG 8939.63 ± 1547.03 10197.42 ± 911.50 11325.64 ± 1143.52 7620.78 ± 1708.66
TAC-1 Synovial membrane 346.28 ± 70.11 132.70 ± 16.78* 362.31 ± 72.70 249.36 ± 99.34
TAC-1 Patellar cartilage 145.37 ± 42.49 86.91 ± 25.93 89.69 ± 24.76 214.74 ± 71.01
CGRP DRG 309931.4 ± 38430.2 370243.6 ± 45187.4 391659.9 ± 35192.5 252244.4 ± 52594.3
CGRP Synovial membrane 68.73 ± 15.55 48.38 ± 18.91 57.44 ± 6.89 24.98 ± 1.42
CGRP Patellar cartilage 43.38 ± 8.47 32.64 ± 9.02 33.98 ± 7.48 120.63 ± 46.56*#
  1. TRPA1, TAC-1 and CGRP mRNA expression in DRG, synovial membrane, and patellar cartilage samples obtained from RT-and cold-exposed mice with 2-week CFA-induced monoarthritis. Data are represented as copy numbers per μl of pure cDNA normalized by comparison to B2M, HPRT and GAPDH in contralateral (saline-injected) and ipsilateral (CFA-injected) sides, n = 4–17, * p < 0.05, relative to saline-treated counterparts, # p < 0.05 relative to RT-exposed CFA-treated counterparts
  2. RT room temperature, CFA complete Freund’s adjuvant, DRG dorsal root ganglia