Elevated levels of faecal calprotectin in primary Sjögren’s syndrome is common and associated with concomitant organic gastrointestinal disease

Table 3 Gastrointestinal discomfort is common in primary Sjögren’s syndrome, based on Visual Analogue Scale for Irritable Bowel Syndrome results

Domain	Control subjects (N = 21)	pSS with FC <50 μg/g (N = 25)	pSS with FC >50 μg/g (N = 25)
Abdominal pain	97	87^a	88^b
Diarrhoea	100	94^b	91^b
Constipation	96	78^a	80^a
Bloating and flatulence	90	77^a	61^b
Vomiting and nausea	100	97^b	97^b
Psychological well-being	93	72^b	89
Influence on daily life	99	94^a	68^b
Average	93	82^a	78^b

FC faecal calprotectin, pSS primary Sjögren’s syndrome
Values are given as medians in millimetres, and higher values indicate less symptoms. Mann–Whitney U test was used to compare groups. Significant differences were identified between control subjects in comparison with both pSS groups. No significant differences were identified between patients with pSS with and without pathological FC testing
^a p < 0.05 compared with control subjects
^b p < 0.01 compared with control subjects

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